Levamisole Hydrochloride/steroidmisty@ycphar.com

CAS 16595-80-5 Levamisole Hydrochloride
Product Name:Levamisole Hydrochloride
Alias:L-Tetramisole 
Molecular Formula：C11H12N2S.HCl
Molecular Weight：240.75
CAS No. 16595-80-5
Purity:99%
Grade:Pharmaceutical Grade
Appearance:White or almost white crystalline powder

Levamisole, marketed under the trade name Ergamisol, is a medication used to treat parasitic worm infections.It has also been studied as a method to stimulate the immune system as part of the treatment of cancer.Levamisole remains in veterinary use as a dewormer for livestock.

Levamisole Hydrochloride (Levamisole HCL), is an anthelmintic (anti-worm) agent commonly used in large livestock such as cattle, pigs and sheep. Currently, Levamisole HCL is used in humans for diseases related to imbalances in the regulation of immune responses or deficiencies of the immune system, including autoimmune diseases, chronic and recurrent diseases, chronic infections and cancer. It has beneficial effects on host defense mechanisms and restores depressed immune responses in animals and humans.  Another interesting use of levamisole in humans is as a treatment for common warts (verruca vulgaris). 

News of its anthelmintic efficacy and immune system benefits has been known among aquatic hobbyists for years. The problem however, is that there is not much in the way of definitive information on its use and application in the hobby. Anecdotal accounts of how it has worked for those ‘outside the box’ aquarists who first braved its use with fish, and accounts of personal experience with Levamisole in individual aquariums are helpful, but the ‘your mileage may vary’ factor is immense. Word about its usefulness in treating internal parasites in the ornamental fish trade has spread, but information regarding its use is limited and sometimes conflicting. From the information I have found thus far, Levamisole HCL is safe to use in aquaria and effective against many internal parasites, especially nematodes, when used in appropriate dosages. It does not harm the bio-filter, plants, invertebrates or uninfected fish. As an added benefit, it boosts the immune competence of fish, humans, large animals, birds and some reptiles.

Pharmacodynamic

Properties Levamisole refers to Levo tetramisole, it is the Levo Isomer of tetramisole. It can selectively inhibit succinate dehydrogenase in parasite’s muscle so as to stop the reduction of succinic acid from fumaric acid. Therefore the parasite’s muscle metabolism lacks of oxygen and leads to decreasing of energy.

L-isomer is active against helminthes with 1-2 times higher active efficiency and lower toxic and side effects than tetramisole. It is a broad spectrum anthelmintic with a very good activity against roundworms, hookworms, whipworms, and strongyloises stercoralis. It is an immunomodulator and has effect on rheumatic disorders.
Levamisole is also a good alternative in cases of benzimidazole resistance.

Side Effect

The most serious side effect of levamisole is low white blood cells that leaves person vulnerable to infection. It belongs to the class of synthetic imidazothiazole derivatives.