High quality peptide powder GDF-8/steroidmisty@ycphar.com

Product Name:GDF-8
Alias:Growth Differentiation Factor 8
Purity : 95%
Specification:1mg/vial
Grade : Pharmaceutical Grade

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene.Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.

High quality peptide powder IGF1 Human Des1-3/steroidmisty@ycphar.com

Product Name:IGF1 Human Des1-3
Alias:IGF1 Des1-3
Molecular formula: C319H501N91O96S7
Molecular Weight : 7371.4 
CAS number: 112603-35-7
Appearance : Fine White Lyophilized Powder
Purity : 98%
Specification:1mg/vial
Grade : Pharmaceutical Grade

IGF1 Des1-3 is a naturally occurring, endogenous protein, as well as drug, and truncated analogue of insulin-like growth factor 1 (IGF-1)IGF1 Des1-3 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1).As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency (about 10-fold in vivo) relative to IGF-1.

IGF-1 DES

DES IGF-1 is the shorter version of the IGF-1 chain. It is five times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it's best used for site injections, rather than overall growth.

In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3.

Dosing and Injections

DES IGF-1 can be dosed at 50-150mcg multiple times a day (prior to training) into specific target areas. since DES has such a short half life (20-30 minutes), desensitization was not noticed at all . Injection sites should be localized; preferably, at the muscle group you want to grow. In simple terms, if you want to grow your biceps, inject IGF-1 DES right into your bicep.

High quality peptide powder ACE-031/steroidmisty@ycphar.com

Product Name:ACE-031
Alias:ACVR2B
CAS NO.:616204-22-9
Molecular Formula:C10H17N3O6S
Purity:85%
Specification:1mg/vial
Appearance:White Powder
Grade:Pharmaceutical Grade

ACE-031 is an investigational protein therapeutic that builds muscle and increases strength by inhibiting molecules that bind to and signal through a cell surface receptor called Activin Receptor Type IIB (ActRIIB). ACE-031 is a recombinant fusion protein that is produced by joining a portion of the human ActRIIB receptor to a portion of a human antibody. This creates a freely circulating, decoy version of ActRIIB which removes proteins, such as GDF-8 (myostatin) and other related molecules that limit the growth and strength of muscle. Muscle growth is regulated by proteins in the TGF-ß protein superfamily that serve as "on" or "off" switches for muscle production. Several molecules including GDF-8 interact with the ActRIIB receptor and send an "off" signal to stop muscle production. In the absence of these "off" switch molecules that signal through the ActRIIB receptor, muscle mass increases dramatically. n nature, this effect has been observed in numerous species, particularly in animals that have been bred for increased musculature and strengt

ACE-031 Benefits

ACE-031 causes a huge increase in muscle mass and muscle strength that can supposedly compete over even the most efficient hardcore volume steroids, such as Oxymetholone.Taking ACE-031 results in the fast and almost immediate increase of muscle hardness.ACE-031 promotes fat burning.

ACE-031 Dosage

Even a small dose of ACE-031 of 1 mg can have a substantial effect. Sportsmen taking 1 mg of ACE-031 once a week over the period of 3-4 weeks report nearly an immediate increase in the muscle hardness and the rapid growth of muscle mass and strength to an extent exceeding even the most efficient hardcore volume anabolic-androgenic steroid, such as Oxymetholone!

Another dosing option is to start with the dose of 200 mcg of ACE-031 per day and to increase the dose every week by 100 mcg, whereas the treatment cycle should last again 3-4 weeks.

Once a cycle with ACE-031 is completed, a break in the duration of two weeks is recommended.

ACE-031 Side Effects

In clinical studies performed by Acceleron Pharma on a sample of adult males (volunteers), some study participants treated with ACE-031 experienced minor nose and gum bleeding and dilation of blood vessels in the skin. The majority of these side effects completely resolved once the treatment with ACE-031 was completed or discontinued.

High quality peptide powder Deslorelin acetate/steroidmisty@ycphar.com

Product Name:Deslorelin Acetate
Sequence : Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt
Cas No. : 57773-65-6
Molecular Formula : C64H83N17O12
Molecular Weight : 1282.47
Purity (HPLC) : 99.0%min.
Appearance : White powder
Single Impurity (HPLC) : 0.5%max
Amino Acid Composition : ±10% of theoretical
Peptide Content (N%) : ≥80.0%
Water Content (Karl Fischer) : ≤8.0%
Acetate Content (HPIC) : ≤12.0%
MS (ESI) : Consistent
Mass Balance : 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8℃ preservation
Usage : Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen).
Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Application:

Deslorelin was successfully trialed in the US and was approved for veterinary use under certain circumstances. In Europe, it was approved for use in equine assisted reproduction.
It is also being trialed in humans to study its efficacy in treatment of breast cancer in women,and in treating precocious puberty and congenital adrenal hyperplasia in male and female children.

High quality peptide powder Follistatin 344/steroidmisty@ycphar.com

Product Name:Follistatin 344
Alias:FST
Appearance:White to off-white crystalline powder or lumps
Grade:Reagent Grade
Specification:1mg/vial

Follistatin Benefits

Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene.Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.

Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin.Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.

Functional Mechanism

An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).

Follistatin works by binding to and inhibiting transforming TGF-β peptides such as myostatin which is responsible for regulating and limiting muscle growth. It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.

In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function. However, FSH levels that are too low can also negatively impact health and reproductive capabilities.

High quality peptide powder Epitalon/steroidmisty@ycphar.com

Product Name:Epithalon,Epitalon
CAS NO.:307297-39-8
Molecular Formula:C14H22N4O9
Molecular Weight:390.3459
Appearance:White Powder
Specification:10mg/vial
Grade:Pharmaceutical Grade
Usage:Tetrapeptide revealing geroprotective effect.

Epitalon is a protein peptide that can stimulate the body's own natural production of telomerase within our it's cells.By doing this, it strengthens telomeres for reproduction. Your body makes telomerase, but it needs to be stimulated with the right precursors.Over time it should lengthen the telomeres of cells and refresh your entire body.

According to scientific studies based on animal test subjects, Epithalon (also known as Epitalon) has been shown to function with telomeres, which are areas of repeating DNA sequences that function to prevent gene degradation near the end of chromosomes.
Over time, telomeres become too small and weak to contain the sequence because of cell division, and the DNA becomes disrupted, which signals the start of the aging process.Epithalon works to replenish the enzyme that allows telomeres to remain more stabilized and better equipped to hold DNA in place.

Application

Epitalon Can Increase Your Physical Energy And Help You Get Deeper, More Restful Sleep
Epitalon Can Extend Your Lifespan Up To 50%,To Live Without Aging And In Perfect Health
Epitalon Can Make Your Body/Joint Pains Disappear, Tighten Your Skin And Facial Features
Epitalon Can Appease Your Anxiety, Anger,Depression, Improve Libido And Your Well-Being
Epitalon Can Improve Your Intellectual Capacity,Labor, Reflexes, Nerve Functions And More

High quality peptide powder Mechano Growth Factor,MGF/steroidmisty@ycphar.com

Product Name:Mechano Growth Factor,MGF
MF: C121H200N42O39
MW: 2888.16
Purity: 99%
Specification: 2mg/vial
Appearance: White Lyophilized Powder
Grade:Pharmarceutical Grade

2 kinds of MGF splice variants of IGF

Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue.  It’s called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the other IGF variants.

IGF-1Ec:This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. 

IGF-1Ea:After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. It is the secondary release of igf from the liver, and its far less anabolic and shorter acting.

The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

MGF Benefits

MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.

In bodybuilding this drug is used to accelerate muscle growth. Other effects of the drug include decrease of fat mass of the body, endurance increase, improvement of immune defenceand skin, bone strengthening, lowering of cholesterol level, accelerated recovery. Those who administered MGF declared that they experienced no side effects, which frequently occur with the use of other drugs for gaining body mass.

Muscle Repair Factor

When you train, what happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant.  The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.

As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker.  In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now, with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages, 200mcg bi-laterally is the very best choice of dosing in muscles trained.

High quality peptide powder TB500/steroidmisty@ycphar.com

CAS 77591-33-4 TB500

Product Name:TB500,Thymosin beta 4 acetate
CAS:77591-33-4
Molecular Formula:C212H350N56O78S
Molecular Weight:4963.50
Specification:2mg/vial
Appearance : White to off-white crystalline powder or lumps
Grade:Pharmaceutical grade

TB500 is part of Thymosin beta 4 acetate

TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. Thymosin beta-4 is a very large molecule. In fact, it is so large that it cannot fit entirely into the receptor. Different sections of the molecule have different activities. TB-500 is the part of thymosin beta-4 hormone which promotes the most useful effects (overall healing, repair, new blood and muscle cells). For medical applications it is more practical to use the TB-500 instead of the entire Thymosin Beta-4 protein.

Promote Healing

The main purpose of TB500 is to promote healing. It also promotes creation of new blood and muscle cells. The healing effects of TB-500 have been observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher concentration where tissue has been damaged. 

TB-500 is specifically designed to help deal with injured athletes and bodybuilders,it is an injectable peptide drug which can be used to promote healing, enhance range of motion in cases of injury, or reduce pain in case of injury by reducing inflammation.This peptide is also a very potent anti-inflamatory agent.

TB500 is a synthetic peptide that has been directly linked to recovery as it is plays a vital role in building new blood vessels, new small muscle tissue fibers, cell migration and blood cell reproduction.  If you are an injured athlete, all of these properties are something that becomes very desirable when looking to speed up the recovery process. 

Dosage and Usage

TB500 is distributed as a lyophilized powder that should be kept out of the light and in a cool dry place.  Reconstitution is done with bacteriostatic water or sodium chloride meant for injection.  Doses range from 2-2.5mg twice weekly for 4-6 weeks (some user have reported success in dosing higher up to 8mg a week but how much more effective this is yet to be seen) .  Beyond that, one to two monthly injections of 2-2.5mg of TB500 can be further utilized to maintain rapid recovery and flexibility in strained areas.

For optimal recovery, a combination of TB500 with MK-2866 (Ostarine) should be used.  This combination allows the healing benefits of SARMS and peptides to delivery maximum results.

Side Effects

The positive attributes of TB500 include blood vessel and cell differentiation, growth of new blood cells from pre-existing vessels in dermal tissue, decreased inflammation and increase in flexibility.  The flu like symptoms or lethargy/head rush associated with most peptides does not seem to be widely reported with TB500.  Everybody is different, so always follow the suggested dosing protocols and practice sterile injection techniques.  This will cut down on environmental side effects associated with injections.

High quality peptide powder Selank/steroidmisty@ycphar.com

Product Name:Selank
Synonyms: Selanc
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molar Mass: 751.8
Purity:98.71%
Specification:5mg/vial
Appearance:White Lyophilized Powder

Selank or selanc is a synthetic heptapeptide analog of the endogenous tetrapeptide tuftsin, with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. This synthetic variant of immunomodulatory tetrapeptide tuftsin possesses anxiolytic properties because of its mimic nature. Among this peptide's positive characteristics, are its ability to induce serotonin’s metabolic processes and affect the concentration of specific monoamine neurotransmitters. Some scientists believe that Selank possesses such modulatory feature as influencing expression of brain-derived neurotropic factor.

Neuropeptide Selank is a synthetic derivative of the human body's naturally produced tetrapeptide Tuftsin. It is a hexapeptide whith a wide range of uses. Selank is used as an anxiolytic in the therapy of anxiety and phobic disorders, including generalized anxiety. Its action is similar to that of mild benzodiazepins but without the sedative effects. As a selective anxiolytic with a nootropic component, Selank can be used as treatment of depression, fear and general anxiety. It also reduces phsychic tension. This neuropeptide has passed all phases of clinical trials and is now being prepared for registration and mass production. 

Selank is closely related to Semax, a hexapeptide previously invented by the same institute. Some consider Selank to be a more efficient alternative to Semax. 

Selank as a Nootropic 

Recreationally Selank is used to improve one's ability to focus and concentrate, reduce mental fatigue, increase mental sharpness and increase memory and learning capacity. The first noticeable effect is usually stabilization of mood and general feeling of well-being. 

Selank as an Antiviral Agent 

Selank neuropeptide also expresses immunomodulatory effects. In 2009 a study by F. Ershov et all. has evaluated antiviral properties of Selank both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2). The pronounced antiviral effect of Selank was detected in both systems. The highest efficiency - completely supressed viral reproduction was shown when Selank was added to the cell culture 24 hours before inoculation. 

Selank effects 

Improvement of learning and memory processes (reference, reference)
Increased sensory attention
Increased curiosity
Increased mental clarity
Restoration of balance of serotonergic and noradrenergic brain system activity (reference)
Anti-anxiety - inhibition of anxiety (reference)
Antiviral activity with no negative effects (reference)
Psychostimulant, anti-asthenic - increased mental energy (reference)
Stabilization of mood and overall feeling of wellbeing
Reversal of anhedonia (restoring the feeling of pleasure)
Potential restoration of catecholaminergic system functions after damage due to drug abuse reference

High quality peptide powder DSIP/steroidmisty@ycphar.com

Product Name:Delta sleep-inducing peptide,DSIP
CAS NO:62568-57-4
Molecular Formula:C35H48N10O15
Molecular Weight:848.81
Purity:99%
Specification:2mg/vial
Grade:pharmaceutical grade

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

DSIP Function

Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies

Roles in endocrine regulation

Decreases basal corticotropin level and blocks its release.
Stimulates release of luteinizing hormone (LH).
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Structure and Interactions

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.

Roles in Disease and Medicine

Anticarcinogenic
Analgesic effect
Geroprotective effects

High quality peptide powder PT-141/steroidmisty@ycphar.com

Product Name:Bremelanotide,PT-141
Alias: Brmelanotice,BreMelanotide Acetate
CAS Registry Number: 189691-06-3
MF: C50H69N15O10
MW: 1040.17736
Appearance: White powder 
Purity:99%
Grade: Pharmceutical Grade 

Developed From Melanotan II

Bremelanotide or PT-141, a research chemical and peptide, belongs to the classification known as melanocyte stimulating hormones (MSH).  It is a hexapeptide analog of alpha-MSH, and was originally developed from the MSH Melanotan II, a peptide agent that was reviewed in trials for sunless tanning but, unexpectedly, resulted in sexual arousal and sexual spontaneous erections in nine of ten test subjects.

Bremelanotide is a compound under drug as a treatment for female and male sexual dysfunction, hemorrhagic shock and reperfusion injury. 

Treatment of Sexual Dysfunction

Bremelanotide or PT-141 is the generic term for a new research peptide for use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arousal disorder). 

PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction.Bremelanotide, PT-141 does not act on the vascular system like the former compounds but it is known and has been shown to help increase sexual activity in both male and female mammals. Bremelanotide PT-141 allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. 

Bremelanotide is a novel treatment that could potentially change the face of treating sexual disorders, not only because of its effectiveness due to a unique mode of action, but also due to its safety and the fact it works synergistically with other ED/SAD treatments.

Bremelanotide is effective in its potential to treat sexual desire disorders as well as disorders that affect physical arousal. Bremelanotide induces lordosis in animal subjects, a sign of physical preparation for copulation. In males, it does not stimulate the vascular aspect of the penis, but instead acts to stimulate the central nervous system primarily via dopamine receptor activity to increase sexual desire and also demonstrates functionality in treating purely physical manifestations of ED/SAD, likely through improved signalling.

Co-administration of PT-141 and Sildenafil 

Bremelanotide also offers potential as a low-dose concurrent treatment with low-dose sildenafil.

The erectile response induced by co-administration of PT-141 and sildenafil was significantly greater than the response elicited by administration of sildenafil alone. Co-administration of PT-141 and sildenafil was safe and well-tolerated and did not result in new adverse events or adverse events that were increased in frequency or severity compared with monotherapy. Co-administration of intranasal PT-141 and a phosphodiesterase type 5 inhibitor may constitute a treatment alternative for patients in whom higher doses of a single therapy are not effective or well tolerated.

High quality peptide powder Pralmorelin GHRP-2/steroidmisty@ycphar.com

Product Name:GHRP-2 (Pralmorelin),Growth Hormone Releasing Peptide-2
CAS: 158861-67-7
Molecular Formula: C42H50N8O5
Molecular Weight: 746.90
Purity (HPLC): 98.0%min.
Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >80.0%
Water Content(Karl Fischer): <6.0%
Acetate Content (HPIC): <12.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8℃ preservation
Usage : GHRP - 2 is a true hGH secretagogue, which help to promote lean body mass and reduce adiposity (fat). GHRP - 2 also has a protective effect on the liver and an anti-inflammatory effect.

Description:

GHRP - 2 is a true hGH secretagogue. Which means it stimulates the body’s own secretion of hGH as explained in the study below. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). ‘The group compared ITT to stimulation with GH releasing peptide 2 (GHRP-2). The synthetic hexapeptide, also named pralmorelin, is derived from a metenkephalin peptide. It is the most potent of the family of synthetic GH stimuli known in humans and acts via the endogenous ghrelin receptor (12). As these receptors have been identified both in the hypothalamus and the pituitary, GHRP-2 action may not be restricted to the pituitary.It has been reported that growth hormone (GH)-releasing peptide-2 (GHRP-2), a ghrelin receptor agonist, has an anti-inflammatory effect.
GHRP-2 is short for Growth Hormone Releasing Peptide 2, which basically refers to an hgH secretagogue, according to some research studies on rats, it can effectively increase the amount of natural secretion of hgH in the test subjects body and secrete it while stimulating the pituitary gland at the same time. Since the test subjects body will end up producing more growth hormones this way, fat will be reduced while lean muscle mass is increased. Along with this, IGF-1 levels will increase, as well, along with the different hypothalamus functions

Application:

The half-life of GHRP-2 is quite short, though, with its peak occurring around 15 minutes after its administration or an hour later at the latest. Ideally, this therapy should be administered periodically everyday.
Similar to GHRP-6, GHRP-2 is its commercially synthesized form that can stimulate the growth hormone secretion much better and stimulate the PRL, cortisol and ACTH levels a little better. For ghrelin, on the other hand, it functions like a synthetic agonist that can connect with the secretagogue receptor of the growth hormone. GHRP-2 can also increase the levels of calcium ion influx and, in turn, release even more growth hormones.
Aside from that, some research has already been done proving how similar it is with the effectiveness of GRF, as well. As a matter of fact, it has proven to be much more potent compared to any other GH-releasing secretors known in the past, including GHRP-1 and GHRP-6. Because of this, this hormone is often used as a treatment for catabolic deficiencies and states nowadays.
GHRP-2 basically acts exactly like ghrelin. It can induce food consumption just like ghrelin and stimulate GH secretion, too. When infused, GHRP-2 makes the GH levels in the body increase a lot and it can induce cell cAMP secretion the way that GRF tends to, as well.
Aside from that, the supplements of GHRP-2 are known to be anti-inflammatory. However, its results tend to differ between research test subjects, depending on how each subject’s pituitary somatotrophs choose to respond based on the different receptor subtypes of GHRP overall.

High quality peptide powder GHRP-6/steroidmisty@ycphar.com

Product Name:GHRP-6 (Growth hormone releasing peptide)
CAS: 87616-84-0
Molecular Formula: C46H56N12O6
Molecular Weight: 873.01
Purity (HPLC): 98.0%min.
Specifications:5mg/vial,10mg/vial
Appearance: White powder
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8℃ preservation

General Information

Growth Hormone Releasing Peptide-6 or GHRP-6 is basically a hgH secretagoue, which has the potential to facilitate the effective increase the levels of natural secretion of hgH in our body. At the same time, this compound can also facilitate a sudden increase in body mass and bring about a massive reduction in body fat. GHRP-6 also includes artificial d-amino acids which lead the body to release growth hormones as well. GHRP-6 is not known to work well with GHRH, so it works at the Ghrelin's receptor in place of that receptor.

GHRP-6 is a compound with a unique chain consisting of 6 amino acids which is responsible for telling our body when it has to start releasing the HGH secretions. GHRP-6 also blocks out somatostatin, a hormone which is primarily responsible for stopping HGH secretions from releasing.

The main use of GHRP-6 is promoting food consumption by initiating the feeling of hunger and to improve a person's energy metabolism. This compound has also been extensively used to treat the deficiency of growth hormone along with other complications like cachexia, obesity, and eating disorders.

Although, GHRP-6 is relatively new in the market it has become quite the rage as performance enhancer. It is being made available the market by a few research companies.

How does it work?

GHRP-6 directly stimulates the anterior pituitary gland which subsequently leads to an increase in the release of growth hormones in the body. As GHRP-6 directly affects the feedback loop which triggers changes in inhibition of the release of Growth Hormones, it can be used to restore the natural manufacturing of the Growth Hormone if natural secretion has been impaired because of long term artificial use. GHRP-6 also reportedly has an impact on our nervous system. They are potentially capable of protecting neurons and increasing the strength of a person. The functioning of GHRP-6 is strikingly similar to the working of several steroids in the DHT family. 

Benefits of GHRP-6 

As discussed earlier, GHRP-6 is a newer drug in the market, but it has caught on the fancy of many who are looking for a shortcut to performance enhancement. The following benefits come after GHRP-6 administration:

Lowers body fat: GHRP-6 administration has the reputation of lowering fat, making it a good option for bodybuilders in their cutting cycles. It is also extremely attractive to those people who are weight conscious and are looking to shed those extra pounds without working hard at the gym.
Increase muscle: GHRP-6 administration also has the reputation of facilitating an increase and development in muscles. 
Increase stamina: Those users who are vouching for the drug claim improvement in stamina levels post the administration of GHRP-6.
Protective and anti-inflammatory: GHRP-6 administration initiates better protection of the muscles and acts as an anti-inflammatory agent which is crucial in the muscle recovery process and synthesis. 
GHRP-6 also ensures that the liver is working to initiate IGF-1 secretions helping you lose fat quicker and gain strength as the time passes by.

Dosing and Usage

Despite it being third in class as far as strength of GH release, GHRP-6 is still a potent GHRP and can be taken 2-3 times per day. Though there is a slight issue, GHRP-6 has been shown to not be as effective in the presence of elevated blood glucose levels. As a result, I believe the best practice for GHRP-6 dosing is to dose 2 hours after your last meal and 30 minutes before you take in any food, so that no interactions weaken the effect of GHRP-6. Taking this into consideration, GHRP-6 can be taken 2-3 times a day (approximately 3 hours in between injections) for maximum effectiveness with a range of 100mcg-200mcg per dose.

Bodybuilding peptide powder Melanotan I/Bodybuilding peptide powder

Alias: Melanotan-1, Melanotan I, Afamelanotide, Melanotan, Melanotropin
CAS: 75921-69-6
MF: C78H111N21O19
MW: 1646.845
Purity: 99%
Specification: 10mg/vial
Appearance: White Lyophilized Powder
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be s

tored at 4° C between 2-21 days and for future use below -18° C.

Usage:
Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α -MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R, MC3-5R). As an analogue of α -MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.

Bodybuilding peptide powder Sermorelin Acetate,GRF 1-29/steroidmisty@ycphar.com

CAS 86168-78-7 GRF 1-29

Product Name:Sermorelin Acetate,GRF 1-29
Alias:Somatoliberin,Sermorelin ,Sermorelinum,Sermorelina,Sermoreline
CAS No.: 86168-78-7
Molecular Formula: C149H246N44O42S
Sermorelin Molecular Weight: 3357.96
Sermorelin Purity (HPLC): 98.0%min.
Sermorelin Appearance: White powder
Specification:2mg/vial
Grade:Pharmaceutical Grade

GRF 1-29
Sermorelin is actually known to us by the name GRF (1-29).  The original GFR (1-29) is, in fact, the root of the HGH molecule and that remaining peptide containing the first 29 amino acids is actually what is responsible for stimulating pituitary response.  The name Sermorelin is the prescription drug name and this alone is why it is so widely prescribed by hormone replacement therapy clinics (HRT).

In fact, anti-aging and hormone replacement clinics have been prescribing GRF 1-29 for years because it works as a clean GHRH.  The problem for the bodybuilder or athlete is that it has a very short half-life of about ten minutes.  This becomes an unattractive feature when compared to the half-life of MOD GRF (1-29) (CJC 1295 without DAC), which comes in around 30 minutes.  Despite its short window, it does bind quite effectively to the pituitary receptors.  The other main down side associated with its very short half life is that it is quickly broken down by blood enzymes within minutes.  This is why a GHRH peptide with a half life of 30 minutes or longer is desirable, since it will survive the blood enzyme death and allow it to circulate the body looking for hormone receptors to bind to.

HRT Function
So, why would bodybuilders or athletes want to utilize Sermorelin over other peptides that have longer half lives like MOD GRF (1-29) or CJC 1295 with DAC?  To put it simply, you could easily work this into a multi-dosing protocol along with you other long acting GHRH’s and GHRP’s.  Let’s look at Sermorelin’s known positive effects like: increased lean body mass, reduced fat, increased strength, improved recovery, better sleep, strengthenining of the heart, enhancing of the immune system and increases IGF-1 production.  Yes, while the ability of Sermorelin to act is short, it still promotes all of these factors stated above.  Not to mention it also has the ability to increase protein synthesis, promote growth of all internal organs with the exception of the brain and promote and increase in liver glucogenesis.  Despite its tiny half life, Sermorelin’s ability to increase IGF-1 in the blood stream will only further increase the function of the metabolism and the growth of new cells in muscles, bones and organs.  Sermorelin is heavily pushed by HRT clinics and is often referred to as the anti-aging peptide since it is very good at reversing some of the effects of aging in adults.  The fact that doctors can legally prescribe this peptide helps HRT clinics further their legitimacy and also offer a viable and more cost effective solution to prescribing exogenous HGH.

Dosage and Usage
Sermorelin, along with the other peptides you will use, comes as a delicate lyophilized powder that should be kept out of the light and in a cool dry place.  Reconstitution is done with bacteriostatic water (BC water) or sodium chloride meant for injection.  Injections can be administered one hour before workout at a dose of 200mcg-300mcg.  Normally, Sermorelin injections are taken before bed at around 300mcgs.  Of course, as with any GHRH, you will want to use this peptide alongside a GHRP like GHRP-2 or Ipamorelin for maximum release of growth hormone stores.  Ideally, though user could still benefit from using a GHRH like CJC 1295 with DAC and a GHRP like Ipamorelin throughout the day and then utilize Sermorelin as a pre-bed timed dose.  Do not discount Sermorelin as simply an anti-aging peptide.  It can still help promote the growth of lean body mass and increase the availability of IGF-1 in the blood stream.

Side Effects
Sermorelin is pretty mild in terms of side effects, but, like most peptides, it has the ability to bring on head rush, flush feeling, some swelling at injection site, dizziness, and nausea.  I could not find any cases where prolactin or cortisol levels were elevated by the use of Sermorelin.  As always, listen to your body and follow a dosing protocol that is in tune with you goals.

Bodybuilding Peptide PT-141/Bodybuilding Peptide

CAS 189691-06-3 PT-141

Product Name:Bremelanotide,PT-141
Alias: Brmelanotice,BreMelanotide Acetate
CAS Registry Number: 189691-06-3
MF: C50H69N15O10
MW: 1040.17736
Appearance: White powder 
Purity:99%
Grade: Pharmceutical Grade 

Developed From Melanotan II

Bremelanotide or PT-141, a research chemical and peptide, belongs to the classification known as melanocyte stimulating hormones (MSH).  It is a hexapeptide analog of alpha-MSH, and was originally developed from the MSH Melanotan II, a peptide agent that was reviewed in trials for sunless tanning but, unexpectedly, resulted in sexual arousal and sexual spontaneous erections in nine of ten test subjects.

Bremelanotide is a compound under drug as a treatment for female and male sexual dysfunction, hemorrhagic shock and reperfusion injury. 

Treatment of Sexual Dysfunction

Bremelanotide or PT-141 is the generic term for a new research peptide for use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arousal disorder). 

PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction.Bremelanotide, PT-141 does not act on the vascular system like the former compounds but it is known and has been shown to help increase sexual activity in both male and female mammals. Bremelanotide PT-141 allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. 

Bremelanotide is a novel treatment that could potentially change the face of treating sexual disorders, not only because of its effectiveness due to a unique mode of action, but also due to its safety and the fact it works synergistically with other ED/SAD treatments.

Bremelanotide is effective in its potential to treat sexual desire disorders as well as disorders that affect physical arousal. Bremelanotide induces lordosis in animal subjects, a sign of physical preparation for copulation. In males, it does not stimulate the vascular aspect of the penis, but instead acts to stimulate the central nervous system primarily via dopamine receptor activity to increase sexual desire and also demonstrates functionality in treating purely physical manifestations of ED/SAD, likely through improved signalling.

Co-administration of PT-141 and Sildenafil 

Bremelanotide also offers potential as a low-dose concurrent treatment with low-dose sildenafil.

The erectile response induced by co-administration of PT-141 and sildenafil was significantly greater than the response elicited by administration of sildenafil alone. Co-administration of PT-141 and sildenafil was safe and well-tolerated and did not result in new adverse events or adverse events that were increased in frequency or severity compared with monotherapy. Co-administration of intranasal PT-141 and a phosphodiesterase type 5 inhibitor may constitute a treatment alternative for patients in whom higher doses of a single therapy are not effective or well tolerated.

Bodybuilding peptide powder Ipamorelin/steroidmisty@ycphar.com

Product Name :Ipamorelin
CAS: 170851-70-4
Molecular Formula: C38H49N9O5
MW:711.853         
Appearance: White powder
Grade : Pharmaceutical Grade
Purity:99%min
Specification:2mg/vial

Ipamorelin is a kind of GHRP

Ipamorelin is a peptidic, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue.It is a pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 that was derived from GHRP-1.

Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog.  Ipamorelin belongs to the most recent generation of GHRPs and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).  The cells that produce and release GH are known as somatotropes.   Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when co-administered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).  

The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.  There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.

Compared to GHRP-2 and GHRP-6

Ipamorelin significantly increases plasma growth hormone (GH) levels in both animals and humans.In addition, ipamorelin stimulates body weight gain in animals.Like pralmorelin and GHRP-6, ipamorelin does not affect prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), or thyroid-stimulating hormone (TSH) levels.

However, unlike pralmorelin (GHRP-2) and GHRP-6, but similarly to growth hormone-releasing hormone (GHRH), ipamorelin does not stimulate the secretion of adrenocorticotropic hormone (ACTH) or cortisol, and is highly selective for inducing the secretion only of GH.

Ipamorelin has a unique property among the GHRP class of peptides.  That property is known as selectiveness.  Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose.  Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.

Ipamorelin Function

Increased energy 
Improved sleep and mood 
Increased lean muscle mass 
Decreased body fat 
Increased healing ability 
Increased collagen production 
No marked effects on FSH, LH, or TSH plasma levels 

Steroid Raw Powder Oxytocin Acetate/steroidmisty@ycphar.com

Product Name:Oxytocin Acetate
Alias:Atonin,Endopituirina,Orasthin,Oxytocinum,Partocon,Pitocin,Piton,Pitupartin,Utedrin,Uteracon
Cas No.: 50-56-6
EINECS : 200-048-4
Molecular Formula: C43H66N12O12S2
Molecular Weight: 1007.19
Purity (HPLC): 98.0%min.
Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >80.0%
Water Content(Karl Fischer): <6.0%
Acetate Content(HPIC): <12.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8℃ preservation
Usage : For induction of labor, postpartum oxytocin, and abortion due to uterine atony or retraction caused by the bad uterus bleeding; understand the placental function reserve (oxytocin challenge test); nasal drops can promote milk ejection.

Oxytocin (Oxt) is a mammalian neurohypophysial hormone. Produced by the hypothalamus and stored and secreted by the posterior pituitary gland, oxytocin acts primarily as a neuromodulator in the brain.
Oxytocin plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes, in particular during and after childbirth; its name, meaning "swift childbirth", comes from Greek, oksys "swift" and , tokos "birth." It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples, lactation. Both childbirth and milk ejection result from positive feedback mechanisms.

Application:

Injected oxytocin analogues are used for labor induction and to support labor in case of difficult parturition. It has largely replaced ergometrine as the principal agent to increase uterine tone in acute postpartum hemorrhage. Oxytocin is also used in veterinary medicine to facilitate birth and to stimulate milk release. The tocolyticagent atosiban (Tractocile) acts as an antagonist of oxytocin receptors; this drug is registered in many countries to suppress premature labor between 24 and 33 weeks of gestation. It has fewer side effects than drugs previously used for this purpose (ritodrine, salbutamol, and terbutaline).

Usage and dosage:

Odinopoeia or oxytocin intravenous drip, once the 2.5 - 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 - 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.
Control postpartum hemorrhage per minute intravenous drip of 0.02 - 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 - 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.
Preparation and specification : oxytocin injection (1) 0.5ml:2.5 units (2) 1ml:5 (3) 1ml units 10 units;
Oxytocin nasal drops 1ml:40 units. The induction of labor or prenatal uterine atony: in 2.5-5 units in 500ml 5% glucose for intravenous drip slowly (10-30 drops / minute), maximum time 20 units. (2). Prevention of postpartum hemorrhage: intramuscular injection of 5-10 on each unit, or 5% glucose solution for intravenous drip.
The main contraindication, heart disease, a caesarean history and more than three fetal maternal disable.